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Year Number of Results
1976 1
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2006 1
2008 1
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2021 1
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Page 1
Endoplasmic Reticulum Stress Induces CAP2 Expression Promoting Epithelial-Mesenchymal Transition in Liver Cancer Cells.
Yoon S, Shin B, Woo HG. Yoon S, et al. Mol Cells. 2021 Aug 31;44(8):569-579. doi: 10.14348/molcells.2021.0031. Mol Cells. 2021. PMID: 34294609 Free PMC article.
Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of liver cancer cells. ...In conclusion, we suggest that ER stress induces CAP2 expression promoting EMT in liver cancers ce …
Here, we demonstrated that endoplasmic reticulum (ER) stress induced CAP2 expression, and which promoted migration and invasion of …
Genomic testing in 1019 individuals from 349 Pakistani families results in high diagnostic yield and clinical utility.
Cheema H, Bertoli-Avella AM, Skrahina V, Anjum MN, Waheed N, Saeed A, Beetz C, Perez-Lopez J, Rocha ME, Alawbathani S, Pereira C, Hovakimyan M, Patric IRP, Paknia O, Ameziane N, Cozma C, Bauer P, Rolfs A. Cheema H, et al. NPJ Genom Med. 2020 Oct 5;5:44. doi: 10.1038/s41525-020-00150-z. eCollection 2020. NPJ Genom Med. 2020. PMID: 33083013 Free PMC article.
We implemented a collaborative diagnostic program in Lahore (Pakistan) aiming to establish the genetic diagnosis, and to asses diagnostic yield and clinical impact in patients with suspected genetic diseases. Local physicians ascertained pediatric patients who had no previ …
We implemented a collaborative diagnostic program in Lahore (Pakistan) aiming to establish the genetic diagnosis, and to asses diagnostic yi …
Molecular diagnosis of multistage hepatocarcinogenesis.
Sakamoto M, Effendi K, Masugi Y. Sakamoto M, et al. Jpn J Clin Oncol. 2010 Sep;40(9):891-6. doi: 10.1093/jjco/hyq099. Epub 2010 Jul 4. Jpn J Clin Oncol. 2010. PMID: 20603246 Review.
We address the activation of different molecular pathways during hepatocarcinogenesis that is especially useful in the diagnosis of pathological multistage human hepatocellular carcinoma. In chronic liver disease, the gene-expression signature as well as the degree of l …
We address the activation of different molecular pathways during hepatocarcinogenesis that is especially useful in the diagnosis of patholog …
Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma.
Sakamoto M, Mori T, Masugi Y, Effendi K, Rie I, Du W. Sakamoto M, et al. Intervirology. 2008;51 Suppl 1:42-5. doi: 10.1159/000122603. Epub 2008 Jun 10. Intervirology. 2008. PMID: 18544947 Review.
Molecular analysis of these lesions would help to develop molecular markers for objective histological diagnosis of early HCC and possibly new serum markers for early detection of HCC. It has been reported that HSP70, CAP2, glypican 3 and glutamine synthetase could serve a …
Molecular analysis of these lesions would help to develop molecular markers for objective histological diagnosis of early HCC and possibly n …
Overexpression of cyclase-associated protein 2 in multistage hepatocarcinogenesis.
Shibata R, Mori T, Du W, Chuma M, Gotoh M, Shimazu M, Ueda M, Hirohashi S, Sakamoto M. Shibata R, et al. Clin Cancer Res. 2006 Sep 15;12(18):5363-8. doi: 10.1158/1078-0432.CCR-05-2245. Clin Cancer Res. 2006. PMID: 17000669
RESULTS: According to real-time quantitative PCR, the level of CAP2 mRNA was up-regulated in early HCC when compared with noncancerous liver tissue, and it was further up-regulated in progressed HCC. We raised a polyclonal antibody against CAP2, which showed …
RESULTS: According to real-time quantitative PCR, the level of CAP2 mRNA was up-regulated in early HCC when compared with noncancerou …
Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression.
Effendi K, Yamazaki K, Mori T, Masugi Y, Makino S, Sakamoto M. Effendi K, et al. Exp Cell Res. 2013 Jan 1;319(1):35-44. doi: 10.1016/j.yexcr.2012.09.013. Epub 2012 Sep 27. Exp Cell Res. 2013. PMID: 23022774
Cyclase-associated protein 2 (CAP2) is a conserved protein that is found up-regulated in hepatocellular carcinoma (HCC). By using zebrafish, combined with HCC cell lines, we further investigated the role of CAP2. The zebrafish CAP2 sequence was 60% identical …
Cyclase-associated protein 2 (CAP2) is a conserved protein that is found up-regulated in hepatocellular carcinoma (HCC). By using zeb …
Early hepatocellular carcinoma with high-grade atypia in small vaguely nodular lesions.
Ojima H, Masugi Y, Tsujikawa H, Emoto K, Fujii-Nishimura Y, Hatano M, Kawaida M, Itano O, Kitagawa Y, Sakamoto M. Ojima H, et al. Cancer Sci. 2016 Apr;107(4):543-50. doi: 10.1111/cas.12893. Epub 2016 Mar 18. Cancer Sci. 2016. PMID: 26797961 Free PMC article.
The immunohistochemical expression of HCC-related markers adenylate cyclase-associated protein 2 (CAP2), heat shock protein 70 (HSP70), Bmi-1, CD34 and h-caldesmon were evaluated. ...HGeHCC showed high levels of cellular and structural atypia and large tumor size. The immu …
The immunohistochemical expression of HCC-related markers adenylate cyclase-associated protein 2 (CAP2), heat shock protein 70 (HSP70 …
A preliminary study of plasma cyclase-associated protein 2 as a novel biomarker for early stage and alpha-fetoprotein negative hepatocellular carcinoma patients.
Chen M, Zheng T, Han S, Zhang L, Bai Y, Fang X, Ding SZ, Yang Y. Chen M, et al. Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):215-21. doi: 10.1016/j.clinre.2014.08.006. Epub 2014 Oct 11. Clin Res Hepatol Gastroenterol. 2015. PMID: 25312778
CAP2 had better sensitivity as compared to AFP (82.6% vs 59.3%) for general HCC, and early stage of HCC patients (78.6% vs 40.4%). In addition, CAP2 is able to complement AFP to predict 82.9% of HCC in AFP-negative patients. ...
CAP2 had better sensitivity as compared to AFP (82.6% vs 59.3%) for general HCC, and early stage of HCC patients (78.6% vs 40.4%). In …
Identification of hepatocellular carcinoma-related genes with a machine learning and network analysis.
Gui T, Dong X, Li R, Li Y, Wang Z. Gui T, et al. J Comput Biol. 2015 Jan;22(1):63-71. doi: 10.1089/cmb.2014.0122. J Comput Biol. 2015. PMID: 25247452
Liver cancer is one of the leading causes of cancer mortality worldwide. ...These genes not only include known HCC-relevant genes such as MT1X, BMI1, and CAP2, but also include cancer genes that were not found previously to be closely related to HCC, such as TACSTD2 …
Liver cancer is one of the leading causes of cancer mortality worldwide. ...These genes not only include known HCC-relevant genes suc …
Multitargeting and antimetastatic potentials of silibinin in human HepG-2 and PLC/PRF/5 hepatoma cells.
Ghasemi R, Ghaffari SH, Momeny M, Pirouzpanah S, Yousefi M, Malehmir M, Alimoghaddam K, Ghavamzadeh A. Ghasemi R, et al. Nutr Cancer. 2013;65(4):590-9. doi: 10.1080/01635581.2013.770043. Nutr Cancer. 2013. PMID: 23659451
Hepatocellular carcinoma (HCC) is the most common sort of primary liver malignancy with poor prognosis. This study aimed at examining the effects of silibinin (a putative antimetastatic agent) on some transcriptional markers mechanistically related to HCC recurrence and me …
Hepatocellular carcinoma (HCC) is the most common sort of primary liver malignancy with poor prognosis. This study aimed at examining …
15 results